personalized medicine

See how a computational pipeline uses next-generation sequencing data to identify genetic alterations that produce cancer-specific antigens.

The field is young, but predicting antigens produced by patients’ malignant cells could yield successful treatments for individuals with a range of cancer types.

There are currently more than two dozen ongoing Phase 1 and Phase 2 trials using different vaccine platforms such as DNA, RNA, synthetic long peptides, and dendritic cells.

Through their effects on metabolism and immunity, bacteria in the gut affect whether medications will be effective for a given patient.

The agency says it has taken various steps to ensure the privacy of participants’ data. 

The nationwide experiment will initially include around 100,000 volunteers.

A preliminary clinical trial finds that the personalized therapy improves survival rates and has no severe side-effects.

Millions of measurements from 23 people who consumed extra calories every day for a month reveal changes in proteins, metabolites, and gut microbiota that accompany shifts in body mass.

Michael Christman oversaw the organization’s well-known biobank and pioneered a personalized medicine initiative.

Zebrafish larvae transplanted with patients’ tumors respond as their human donors do to chemotherapy.

Meet some of the people featured in the April 2017 issue of The Scientist.

Measuring PD-L1 levels was a great start. Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too.

The challenges of adapting drug development to the age of personalized therapies encourage collaboration among industry players.

With few resources and hesitant investors, basic scientists must rely on clinicians, patient advocates, and their own keen eye for biological connections.

Brexit's effect on science, melding disciplines, and more

As researchers sequence the DNA of thousands of kids with autism, dozens of genetic subgroups are emerging.

Researchers aim to leverage new insights into the underlying causes of the disorder to better help patients. 

Scientists can now buy the direct-to-consumer sequencing product, and research participants can join 23andMe’s database.