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T-cell targeting cancer cells
Cell-Based Assays for Immuno-Oncology
Cellular immunogenicity and immunotoxicity assays help scientists design, validate, and translate therapeutic research into treatments that weaponize the immune response against cancer.
Cell-Based Assays for Immuno-Oncology
Cell-Based Assays for Immuno-Oncology

Cellular immunogenicity and immunotoxicity assays help scientists design, validate, and translate therapeutic research into treatments that weaponize the immune response against cancer.

Cellular immunogenicity and immunotoxicity assays help scientists design, validate, and translate therapeutic research into treatments that weaponize the immune response against cancer.

Immunology

Microscopy image of hepatocytes stained in pink with purple nuclei.
Liver Proteins Keep T Cells Out of Tumors
Aparna Nathan, PhD | Jun 21, 2024 | 4 min read
A new study finds an unexpected role for hepatocytes in anticancer immunity.
Vaccines and Beyond: Strategies and Technologies for mRNA Therapeutics
Vaccines and Beyond: Strategies and Technologies for mRNA Therapeutics
The Scientist Staff | Jun 19, 2024 | 2 min read
An expert panel will discuss mRNA-based vaccines, current approaches and challenges, and how researchers are moving RNA therapeutics forward in exciting new directions.
Infographic showing how flow cytometry enables researchers to assess several cell parameters simultaneously at a single-cell level with the help of lasers.
Flow Cytometry: Scattering Light to Measure Cells
Shelby Bradford, PhD | Jun 14, 2024 | 2 min read
Scientists analyze and quantify characteristics of cells and other particles with the power of lasers.
A cell with gold particles inside is hit with a red laser.
How Flow Cytometry Spurred Cell Biology
Shelby Bradford, PhD | Jun 14, 2024 | 10+ min read
The ability to rapidly count and measure features of cells opened the research flood gates.
Microglia and glial cells
CRISPR-Ready Cells for Target Discovery 
bit.bio | Jun 13, 2024 | 1 min read
A new iPSC-derived cellular tool with built-in Cas9 expression enables high efficiency knockout screening for drug target identification and validation.
Spherical viruses with spiked membrane proteins on their surfaces surround larger suspended cancer cells. 
Introduction to Oncolytic Virotherapy 
Amielle Moreno, PhD | Jun 13, 2024 | 8 min read
Oncolytic virotherapy selectively attacks tumors and triggers both immediate and long-lasting immune responses. 
Fluorescent microscopy image with a black background and blue, green, and red colors marking different cells.
A Safe-Haven for Intestinal Viruses
Aparna Nathan, PhD | Jun 11, 2024 | 4 min read
A rare gut cell puzzles researchers by avoiding immune cells.
3D illustration of purple neurons.
An Immune Mechanism Maintains Memory
Shelby Bradford, PhD | Jun 10, 2024 | 4 min read
A receptor that recognizes DNA fragments formed during learning is necessary for proper memory formation.
Four circular maps of color-coded immune cell types corresponding to the four tumor microenvironment archetypes.
A Bird’s Eye View of the Tumor Microenvironment
Kamal Nahas, PhD | Jun 3, 2024 | 3 min read
Immune cells form different communities throughout a tumor, potentially disrupting how cancers respond to treatments.
Concept illustration of the placenta
Shifting Parturition Perspectives in Perinatology Research
Deanna MacNeil, PhD | Jun 3, 2024 | 1 min read
Nardhy Gómez-López investigates the placental immunology of preterm birth.
Larger green cell with two cyan spots and many smaller magenta circles in and around the cell. 
Synthetic Systems for Studying Natural Cells
Danielle Gerhard, PhD | Jun 3, 2024 | 2 min read
Oskar Staufer engineers synthetic systems to explore cancer biology.
Snake slithering across dirt. 
Snaking Towards Synthetic Antivenoms
Danielle Gerhard, PhD | May 31, 2024 | 6 min read
After more than a century of producing animal-based antivenoms, scientists turned to synthetic systems to develop safer and more effective snake bite treatments.
A 3D spherical neutrophil animation with a pink, polysegmented nucleus
The Nucleus’ Secret to Shapeshifting
Kamal Nahas, PhD | May 31, 2024 | 4 min read
Neutrophils contort their nuclei into various shapes by moderating one key regulatory protein previously shown to orchestrate DNA organization.
Green bacteria on a blue background.
Mutations Wire Salmonella to Last
Mariella Bodemeier Loayza Careaga, PhD | May 28, 2024 | 4 min read
Genetic changes attenuated Salmonella’s virulence, potentially enabling the bacteria to cause chronic infections in humans.
An illustration showing the DNA inside an immune cell. Other immune cells are shown in the background. 
Keeping CAR T Cells Sharp 
Aparna Nathan, PhD | May 21, 2024 | 4 min read
The FOXO1 transcription factor boosts T cells’ memory and reduces dysfunction.
3D illustration depicting white and red blood cells flowing in a network of blood vessels.
How Migrating Cells Navigate Biological Mazes
Laura Mac-Daniel, PhD | May 16, 2024 | 4 min read
A key protein that detects changes in plasma membrane curvature guides immune-like cells through environmental obstacles.
The feet of several runners wearing brightly colored shoes.
How Exercise Sparks, then Soothes, Inflammation
Rachael Moeller Gorman | May 15, 2024 | 4 min read
Regulatory T cells in muscles surge after exercise, quelling inflammation, protecting mitochondria, and enhancing performance.
An illustration of a<em >&nbsp;</em>macrophage internalizing <em>Staphylococcus aureus</em> through phagocytosis and presenting antigens to a T cell with many bacterial cells surrounding the immune cells.
Tackling a Pathogen That Leaves a Lasting Impression
Charlene Lancaster, PhD | May 6, 2024 | 5 min read
Staphylococcus aureus vaccine efficacy depends on the immune imprints from past exposures to the microbe.
Painless Protein Profiling Through Advanced Multiplexing
Painless Protein Profiling Through Advanced Multiplexing
The Scientist Staff | May 2, 2024 | 1 min read
Learn how to measure 115 biomarkers in one multiplex panel.
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