Four intestinal samples extracted from Drosophila flies: a normal intestine (white), a larger-than-average intestine with a mutated FMR1 gene (red), a smaller-than-average intestine with a different mutation (green), and an intestine with both mutations (yellow) ARTHUR LUHUR, INDIANA UNIVERSITYFragile X syndrome is caused by a mutation in a single gene, which encodes Fragile X mental retardation protein. Scientists have taken a close look at how this protein affects tissue growth, finding that it limits the expansion of a stem cell population during intestinal growth in Drosophila flies.
A. Luhur et al., "Opposing post-transcriptional control of InR by FMRP and LIN-28 adjusts stem-cell based tissue growth," Cell, doi:10.1016/j.celrep.2017.11.039, 2017.
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